Tuesday, October 1, 2013
IS BREAST CANCER ONE DISEASE?
One of the most important discoveries concerning breast cancer has been the realization by many scientists that breast cancer is many diseases.
Have you heard of HER-2 and what does that mean if your cancer is HER-2 positive?
HER-2 stands for human epidermal growth factor receptor-2. This protein can promote the growth of cancer cells. One in every 5 breast cancers makes too much HER-2 due to a gene mutation. This causes the cancer to be more aggressive; however treatment that specifically targets HER-2 is very effective.
This discovery was made by a group of researchers lead by Dr. Dennis Slamon, Head of the Revlon/UCLA Women’s Cancer Research Program. He states that “ there is a molecular diversity of human cancers that has largely gone unappreciated , and it has gone unappreciated because we lump things together.” Dr. Slamon and his team looked at this HER-2 protein and found that if an antibody was added to the receptor gene that had mutated , tumor growth dropped dramatically. Hence the “ birth” of the drug Herceptin to treat HER-2 Positive breast cancers.
More and more we are learning about the genetics of breast cancer and how individualized each women’s cancer may be. As we learn more about the molecular differences we are learning more about treatments for each individual patient.
If you would like to hear more from Dr. Slamon he will be a guest at this year’s Breast Cancer Coalition Conference at the Harrisburg Hilton on October 15, 2013. This conference is open to patient’s and families as well as caregiver’s.
More information: PinnacleHealth Breast Care Center
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Breast cancer is a multifaceted disease characterized by the uncontrolled growth of cells in breast tissue. It is a complex and heterogeneous condition with various subtypes and characteristics. The two most common types are Invasive Ductal Carcinoma (IDC) and Invasive Lobular Carcinoma (ILC), which begin in the milk ducts and spread to nearby tissues. There are also several subtypes and variations of breast cancer, each with unique features, genetic factors, and potential treatment approaches. Some breast cancers are hormone receptor-positive or negative, and some may overexpress specific proteins like HER2. The diversity of breast cancer types necessitates individualized treatment plans, which may include surgery, radiation therapy, chemotherapy, hormone therapy, targeted therapy, or a combination of these approaches. Understanding the specific subtype of breast cancer is crucial for determining the most effective treatment and management strategies.virginia statute of limitations personal injury
ReplyDeleteDr. Dennis Slamon's research on HER-2 positive breast cancer has significantly impacted our understanding of the disease. His work led to the development of Herceptin, a targeted therapy that has proven effective in treating this subtype. His understanding of breast cancer as a spectrum of diverse subtypes is crucial for tailoring therapies to individual patients. His presence at the Breast Cancer Coalition Conference in 2013 provided valuable insights into the latest advancements in breast cancer research and treatment options. Dr. Slamon's dedication to understanding the genetics of breast cancer underscores the potential for more precise and effective treatments. His dedication to individualized patient care is inspiring, as it continues to progress towards more targeted, personalized approaches to combat this complex disease. abogado de lesiones personales playa de virginia
ReplyDeleteBreast cancer is a diverse group of diseases characterized by uncontrolled cell growth in breast tissue. It is classified into several subtypes, each with unique characteristics, behaviors, and treatment responses. The main types include Ductal Carcinoma In Situ (DCIS), Invasive Ductal Carcinoma (IDC), Invasive Lobular Carcinoma (ILC), HER2-positive breast cancer, Hormone Receptor-Positive breast cancer, and Triple-Negative breast cancer.
ReplyDeleteDCIS is a non-invasive or pre-invasive cancer found in the lining of a breast duct but not spreading outside. IDC is the most common type, affecting 70-80% of cases. ILC begins in milk-producing glands and can spread to nearby tissues. HER2-positive breast cancer overexpresses a protein called HER2, promoting cancer cell growth. Hormone receptor-positive breast cancers are characterized by the presence of hormone receptors on cancer cell surfaces, which can be treated with hormone therapies. Triple-negative breast cancer lacks estrogen receptors, progesterone receptors, and HER2 expression, making it more aggressive and challenging to treat.
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ReplyDeleteThe discovery of HER-2’s role in breast cancer — where one in five cases overproduce this protein due to a gene mutation — has transformed how we approach treatment. While HER-2 positive cancers tend to be more aggressive, targeted therapies have brought hope, offering highly effective results. It’s a powerful reminder of how personalized approaches can make a difference, not just in medicine but in everyday life too. It’s a bit like wearing personalized Velcro name patches — a small, individualized touch that identifies something unique about you. In the medical world, precision treatments for HER-2 positive cancers work similarly, zeroing in on the unique biological “patch” that sets this type of cancer apart, offering patients a more tailored, effective path to recovery.
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